The Max Perutz Prize of the European Crystallographic Association



Call for nominations for the 5th Max Perutz Prize Award.

The European Crystallographic Association (ECA) invites nominations for the Fifth Max Perutz European Crystallographic Association Prize to recognize a significant achievement or discovery in crystallography, ideally during the past 5-10 years. Nominees should be affiliated or identified with the European crystallographic community, as broadly defined in the charter of the ECA (see the ECA-news site: www.ecanews.org).

The Perutz Prize is awarded in recognition of meritorious achievements in any branch of crystallography by a crystallographer having a clear affiliation with the ECA region. It can be for leadership or scientific contributions or both.

The prize, including a monetary award and certificate of recognition, will be awarded at the opening ceremony of the 26th European Crystallography Meeting (ECM-26) to be held in Darmstadt, Germany, 29 August -2 September 2010.

The previous laureates are:

Nominators must be (i) an ECA individual Member or (ii) any person from a member country associated to the ECA or (iii) any member from the CAMs. Nominations for the prize should indicate briefly why the candidate is nominated, include a statement of the contribution for which the prize is to be awarded and an abbreviated curriculum vitae [ca. 2 pages] of the nominee. It may include aspects such as publication record and impact, however, uniqueness (i.e. pioneering contributions) and the importance/usefulness of the nominee's work will always be of prime importance in awarding the prize. The nominator must ensure a signed acceptance of the nomination by the nominee.

Where an Awardee's research is in collaboration, the credits to the team or to particularly relevant partnerships are naturally expected to be acknowledged by the Awardee and thereby to be specifically requested in the formal announcement drafting step.

Nominations should be sent by e-mail, no later than 28 February 2010 to:
Prof Andreas Roodt
Dept of Chemistry
University of the Free State
PO Box 339, Bloemfontein 9300
SOUTH AFRICA
Tel.: +27-51-4012547 /9212
Fax: +27-51-4446384
e-mail:


Announcement re the ECA 4th Max Perutz Prize Award.

It is with regret that it is announced that Dr Lynne McCusker has decided not to accept the 4th Max Perutz Prize after all.

Extended discussions with Dr McCusker to reconsider her decision have not been successful.

In her correspondence to me as Chair of the Prize Selection Committee Lynne stated the situation in essence as follows:-

"Unfortunately, when I accepted the prize initially and discussed the wording for the website and for the certificate, I had not realized just how one-sided the recognition would be. That only became apparent to me in Istanbul, and I reacted immediately thereafter. I am very sorry to hear that the Max Perutz Prize Committee and the ECA Executive Committee do not deem it possible to include Christian [Baerlocher]* as a co-recipient of the prize or even to change the wording on the website to give credit more appropriately. If indeed the Max Perutz Prize Committee was under the impression that I am the leader of our team, they were mistaken (there just isn't one), and it seems then that the final decision was made on the basis of incorrect information."
*Christian = Dr Christian Baerlocher

Overall the implication is that there is therefore no final prize winner for the 4th Max Perutz Prize as announced previously and awarded for 2009 in Istanbul at ECM25.

The Executive Committee of ECA regrets Dr. McCusker's decision, but accepts her explanatory statement.

Prof Andreas Roodt, Chairman of the Max Perutz Prize Selection Committee


From the ECA President:

The Perutz Prize Selection Committee is an independently convened group that works in confidence to discuss candidacies for the Perutz Prize Award. The Selection Committee is chaired by a Member of the ECA Executive Committee but which then monitors due process through general reports from the Chairman but in no way is involved in the details of the deliberations or conclusions on the individual candidacies of the Selection Committee. The ECA Executive Committee confirms that due process was followed at all steps by the 4th Award Selection Committee in making this Award. Specifically I mention that after the 4th Perutz Prizewinner was identified, the then ECA President, Prof John R Helliwell informed Dr McCusker in June 2009, and discussed with her by telephone and then email the draft quote for the ECA website that he had received from the Selection Committee Chairman, modified it with her consent, and it was then published as such. After approximately one month, in July 2009, the Selection Committee Chairman contacted Dr McCusker again to discuss a shorter version of the quote to be put on the Prize certificate, with her input. No objection was received from Dr McCusker to awarding the prize as published publicly on the ECA website and announced elsewhere for this nearly 2 months period; this only happened after the Prize was awarded. The difficulties faced by Dr McCusker were raised by her with Prof John R Helliwell by email after ECM25, who was by then out of contact on holiday. The two Committees involved carefully deliberated the matters raised through September 2009. Dialogue with Dr McCusker was then undertaken by the Chairman of the Selection Committee in consultation with the Selection Committee. The ECA Executive Committee confirm that all due care and attention had been exercised by the Selection Committee and Officers involved in the process leading up to the Award itself. The request to make the Prize a two persons team was deemed inappropriate as the Prize conditions do not invite team nominations of 2, 3 or 4 etc persons. Thus the decision of the ECA Executive Committee was that a retrospective decision to alter from a single person awardee to a two-persons award would have potentially discriminated against efforts involving other teams who might have been nominated if that had been announced in the first place.

The Executive Committee of ECA regrets Dr. McCusker's decision, but accepts her explanatory statement.

To be clear:- The Perutz Prize is awarded in recognition of meritorious achievements in any branch of crystallography by a crystallographer having a clear affiliation with the ECA region. It can be for leadership or scientific contributions or both. Where an Awardee's research is in collaboration, the credits to the team or to particularly relevant partnerships are naturally expected to be acknowledged by the Awardee and thereby to be specifically requested in the formal announcement drafting step.

The call for Nominations for the 5th Perutz Prize Award has a closing date of February 28th 2010. The 5th Awardee will present his or her Lecture at ECM26 in Darmstadt, Germany.

Prof Santiago Garcia-Granda, President of the ECA


FOURTH MAX PERUTZ ECA PRIZE

The European Crystallographic Association has awarded the fourth Max Perutz Prize to

Dr. Lynne B. McCusker

The 4th Max Perutz Prize of the European Crystallographic Association goes to Dr. Lynne B. McCusker from the Laboratory of Crystallography at the ETH in Zurich, Switzerland.

Lynne McCusker is recognized for outstanding contributions to structure determination methodologies for polycrystalline materials, which includes software development for powder diffraction and the structure solution of complex porous and zeolite materials with novel framework structures. Her success in solving the structures of these complex materials is due to a combination of many different methods and new phasing techniques based on charge flipping, histogram matching, structure envelopes, electron microscopy and precession electron diffraction. These contributions towards developing new methodologies have enabled her to solve highly complex and important structures at the limits of powder diffraction.

Dr. Lynne B. McCusker will give an acceptance Lecture at the Opening Ceremony of ECM25.




THIRD MAX PERUTZ ECA PRIZE

The European Crystallographic Association has awarded the third Max Perutz Prize to

Prof. David Stuart

The third Max Perutz Prize of the European Crystallographic Association for 2007 is awarded to Prof. David Stuart in recognition of his impact in the field of virus crystallography. Prof Stuart is based at The Wellcome Trust Centre for Human Genetics in Oxford, UK

His research on virus structure, assembly and interactions with receptors not only includes detailed work on some of the most complex and relevant macromolecular assemblies currently amenable to crystallographic study, but also aims at developing vaccines and treatments of diseases.

He performed exceptional experiments in determining the largest crystal structures ever solved: viruses of 100Mda. His work is extensive and he has published more than one hundred papers in the past decade, seven of them in Nature and six in PNAS. Eight of these papers have been cited more than 100 times.

In summary, David Stuart is one of the pioneers of virus crystallography in the world and the ECA Prize 2007 is in recognition of his impact in this field, and his contributions to the structural chemistry of disease at the atomic level.

THIRD MAX PERUTZ ECA PRIZE



SECOND MAX PERUTZ ECA PRIZE

The European Crystallographic Association has awarded the second Max Perutz Prize to

Prof. Eleanor J. Dodson

for developing, implementing, teaching and applying the best tools available to produce macromolecular structures of highest quality.

Eleanor Dodson is an unusual scientist who has made unusual and remarkable contributions. Since the early years of working on insulin together with Prof. Dorothy Hodgkin, she has been at the center of the mathematical side of macromolecular crystallography and has been developing, implementing, teaching and applying the best tools available to produce science of highest quality.

Protein crystallography is a science that requires skills from many disciplines. The areas range from cell biology over DNA technology and the means to express exotic proteins in large quantities to statistical and mathematical methods to achieve optimal diffraction measurements and phase angle determinations with different methods and to validate the determined structures. Eleanor Dodson has throughout her career been engaged in the methodology in macromolecular crystallography, developing, implementing and applying mathematical and statistical methods for data collection and phasing (molecular replacement), refinement (maximum likelihood refinement of protein structure), and structure validation. This is only partly evident from her publication record. However, she has an extensive list of publications (close to 60 publications in the period 1995-2004), many of them in highly prestigious journals with outstanding number of citations (one method-paper received ~2100) showing the high impact and practical importance of her research.

Eleanor Dodson is also recognised as the leading scientist in the creation and development of the CCP4 program suite (Collaborative Computational Project No. 4 of the UK Research Councils) for Macromolecular Crystallography, which is now widely used by the community throughout the world and has had a huge global impact in crystallographic science. CCP4 is constantly updated and improved and is freely and easily available to the community. She also regularly tends to queries placed on the CCP4 bulletin board by students and postdocs needing help and she has also been a frequent and exellent teacher at a large number of crystallographic schools. Thus, she had a tremendous impact on all young scientists that had the priviledge of learning from her teaching, her experience and from her always open heart and friendly attitude. She has also taken on the responsibilities of being a coeditor of J Appl Cryst.

Eleanor Dodson has all the time stayed close to the biological problems. She has been involved in numerous new protein structures. A major highlight, where she had the pivotal role, was the 11-fold NCS symmetry found in the "TRAP" protein. TRAP is an RNA-binding attenuation protein. The 11-fold NCS crystallography result clarified a spread of published estimates for the number of subunits from molecular biology and biochemistry. The self rotation function and its interpretation is a masterly piece of work where Dodsonfs strengths in molecular replacement are profoundly on show.

Eleanor Dodson is an outstanding scientist who sustained very strong contributions for many years and has contributed new methods, software and structures for many years. Eleanor Dodson is highly qualified to receive the 2006 ECA Max Perutz Prize.

Second Max Perutz Prize




2004 Max Perutz Prize of the European Crystallographic Association upTOP


 

The European Crystallographic Association has awarded the 2004 Max Perutz Prize to Professor George Sheldrick

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Professor George Sheldrick is one of the most widely known crystallographers in the field. He made seminal contributions to the development of direct methods and helped to transfer the methodology into a straightforward procedure for solving small molecule structures. He has made significant contributions to structural chemistry and has published well over 700 publications in leading international, peer-reviewed journals. In recent years, his work has also become very important in biological crystallography, in the areas of structure solution based on anomalous phasing and in the refinement of protein structures at atomic resolution.

His program SHELX, which is constantly evolving, has underpinned the automation of chemical X-ray crystallography in the past three decades, and allowed the method to become a routine tool for physical and organic chemists. SHELX is the most comprehensive, reliable, and useful program for the determination and refinement of crystal structures from diffraction data. SHELX is the most cited software in crystallography and its continual use is in fact part of the foundation on which the remarkable success of our discipline rests: a large proportion of the several hundred thousands of crystal structures that have been determined owe their 'existence' to SHELX. The wealth of information available in the Cambridge Structural Database rests firmly on structures determined using his software. The free availability of the SHELX programs to the academic community has been especially important, setting a standard for others to follow. In the past fifteen years, Professor Sheldrick has focused his research on the problems of macromolecular structure determination. He has pioneered the use of direct methods for large molecules containing many atoms when atomic resolution data is available, building on the ideas of dual space refinement to provide an easy-to-use powerful phasing package in the program SHELXD. This has proved that size alone is not an insurmountable barrier when modern computing resources are exploited. This has fostered a new attitude in macromolecular crystallography by showing that with proper treatment even the biggest macromolecular structures can be refined to a level that is not very far from what has been traditionally reserved for small molecules. However, the most frequent application of SHELXD is in locating the anomalous scatterers in protein structures, a prerequisite to structure solution using anomalous phasing. His accompanying program SHELXE takes the process one step further, rapidly calculating the phases required to produce an electron density map and using a novel density modification procedure to resolve the phase ambiguity for SIR or SAD data.

George Sheldrick is head of Department for Chemistry at the University of G?ttingen. He is an excellent and dedicated teacher. His graduate students and young colleagues carry on his research traditions, and they can be found in many European laboratories. He also contributes to many workshops and training courses throughout Europe. His lucid lectures, and his deep understanding of crystallography delight students, and other participants.

George Sheldrick's contributions to crystallography have previously been recognized by many international awards including:

 

The previous laureates are

2000 Prof. Ada Yonath , Weizmann Institute of Science in Israel

2001 Prof. Jochen R. Schneider, HASYLAB at DESY in Germany

2003 Prof. Carmelo Giacovazzo, University of Bari, Italy

 

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ECA Prize 2003 to Professor Carmelo Giacovazzo upTOP


The European Crystallographic Association is to award the third European Crystallography Prize to Prof. Carmelo Giacovazzo of the University of Bari, Italy. Prof. Giacovazzo is being recognized for his major theoretical and practical contributions to the solution of the phase problem in a wide spectrum of applications.

The European Crystallography Prize, which includes a monetary award as well as a certificate of recognition, will be presented during the Opening Ceremony of the upcoming 21st European Crystallographic Meeting  to be held in Durban, South Africa, August 24-29, at which Prof. Giacovazzo will describe the work for which he is being honoured.

Members of the European Crystallography Prize Committee, who were appointed by the Executive Committee of the European Crystallographic Association are: Professor Davide Viterbo (Coordinator), University of Piemonte Orientale, Italy; Professor Leonid Aslanov, University of Moscow, Russia; Professor Boris Kamenar, University of Zagreb, Croatia; Professor Åke Kvick, European Synchrotron Radiation Facility, Grenoble, France;  Professor Dino Moras, University of Strasbourg, France; Professor Jochen Schneider, HASYLAB at DESY, Hamburg, Germany; Professor Xavier Solans, University of Barcelona, Spain.

Prof. Giacovazzo was born in Locorotondo (Bari), Italy and studied Physics in Bari. He is Full Professor of Mineralogy at the University of Bari and Director of the CNR Institute of Crystallography. After a first period dedicated to the study of defects in minerals, he has devoted his research interests do the development of Direct Methods for the solution of the phase problem. His main theoretical contributions are the Representation Theory and several probabilistic formulae for the estimate of structure invariants and seminvariants. From the practical point of view he has directed and coordinated a research group for the implementation of widely used computer programs for the solution of crystal structures not only from single crystal data but also from powder diffraction data. More recently he has developed new and powerful methods for solving ab-initio macromolecular structures using data collected at atomic resolution. He has also provided a new probabilistic approach for the location of the heavy or anomalous scatterers in SIR-MIR-SAD-MAD techniques and for the subsequent phase estimation.


downECA Prize 2001 to Professor Jochen R. Schneider  TOP


The European Crystallographic Association is to award the second European Crystallography Prize to Prof. Jochen R. Schneider of the HASYLAB at DESY, Hamburg, Germany. Prof. Schneider is being recognized for his pioneering work on the application of gamma-ray spectroscopy and his high energy synchrotron radiation studies, as well as his more recent involvement in the development of the free electron laser.
The European Crystallography Prize, which includes a monetary award as well as a certificate of recognition, will be presented during the Opening Ceremony of the upcoming 20th European Crystallographic Meeting  to be held in Krakow, Poland, August 25-31, at which Prof. Schneider will describe the work for which he is being honored.

Members of the European Crystallography Prize Committee, who were appointed by the Executive Committee of the European Crystallographic Association are: Professor Ivar Olovsson (Coordinator), University of Uppsala, Sweden; Professor Roland Boese, University of Essen, Germany; Professor Michael Glazer, University of Oxford, UK; Professor Boris Kamenar, University of Zagreb, Croatia; Professor Åke Kvick, European Synchrotron Radiation Facility, Grenoble, France;  Professor Xavier Solans, University of Barcelona, Spain; Professor Ada Yonath, Weizmann Institute of Science, Israel.

Prof. Schneider was born in Burgst?t, Saxony, Germany and studied Physics in Hamburg after an education as electrical engineer. He did his PhD under the direction of Prof. H. Maier-Leibnitz at the Institute Laue-Langevin in Grenoble, France. His work on gamma-ray diffractometry and Compton scattering was performed at the Hahn-Meitner-Institut in Berlin, the synchrotron radiation work at DESY-HASYLAB in Hamburg, where he is now heavily involved in the development of free-electron lasers driven by linear accelerators. Prof. Schneider is presently Head of HASYLAB and Director of Research for Synchrotron Radiation and Free-Electron Lasers at DESY.


ECA Prize 2000 to Professor Ada Yonath up  TOP


The European Crystallographic Association has awarded the first European Crystallography Prize to Professor Ada Yonath of the Weizmann Institute of Science Rehovoth, Israel and the Max-Planck Research Unit for Ribosomal Research, DESY, Hamburg, Germany, for her pioneering achievements in structural studies on the ribosome, the universal cellular organelle on which protein biosynthesis takes place.

The European Crystallography Prize has been presented at the 19th European Crystallography Meeting in Nancy, France, August 25-31, at which Professor Yonath described the work for which she is being honored.

Professor Yonath was born in Jerusalem and received her Ph.D. under the direction of Prof. Wolfie Traub at the Weizmann Institute, where she is the incumbent of the Martin A. Kimmel Chair in Structural Biology and Head of the Kimmelman Center for Biomolecular Assemblie s. Her pioneering work over many years in pursuit of the ribosome structure which she has orchestrated on an international scale, has been concentrated in Europe, with a significant portion her activity centered at the Max-Planck Research Unit in Hamburg, which she also heads.